Daily post-exposure prophylaxis (PEP) with single tablet emtricitabine/tenofovir/rilpivirine (Complera, Eviplera) has excellent completion rates and good side-effect and safety profiles, Australian investigators report in the online edition of Clinical Infectious Diseases.
The open-label, non-randomised study involved 100 men who have sex with men (MSM) requiring PEP after possible sexual exposure to HIV. Treatment lasted 28 days and was completed by 92% of participants. Side-effects were mild, the most common being nausea and tiredness. There were no serious adverse events.
Prompt PEP, after possible sexual or occupational exposure to HIV, can reduce the risk of infection. Guidelines recommend triple-drug therapy, ideally commenced within 72 hours of exposure. Failure of PEP has been linked to poor treatment adherence or the premature discontinuation of treatment. A recent analysis of 97 PEP studies found that only 57% of patients completed their four-week course of treatment.
The combination pill emtricitabine/tenofovir/rilpivirine provides well tolerated and easy-to-take once-daily HIV therapy. Though it must be taken with food, investigators from Australia hypothesised that the combination pill would provide convenient and safe PEP.
The increasing demand for pre-exposure prophylaxis (PrEP) is likely to increase the likelihood that some marginalised individuals living with HIV sell some of their prescribed medication to pill brokers and drug dealers, according to a study presented to the Conference of the Association for the Social Sciences and Humanities in HIV in Stellenbosch, South Africa last week.
Steven Kurtz told the conference that several reports have documented street markets for diverted antiretrovirals (ARVs) in the United States. His own research focuses on south Florida, where he recruited 147 HIV-positive men who have sex with men (MSM) who regularly use cocaine, crack or heroin. He purposively sampled (over-recruited) individuals who had sold or traded their antiretrovirals, so that he could better understand the factors associated with doing so.
Economic vulnerability is the key explanation. Within this sample, men who had recently sold ARVs were more likely to have an income below $1000 a month, to have traded sex for money or drugs and to be dependent on drugs. Age, race and education were not relevant factors. Unsurprisingly, men who had sold their HIV treatment had poor levels of adherence to it.
Continue reading on aidsmap.com.
From the Advocate.com…
Professors of Sociology at Rice University have found that bisexual Americans face higher health disparities than their gay, lesbian, and straight counterparts. A variety of these health issues stem from systemic socioeconomic vulnerability in the bisexual community, according to the new study.
“As a group, bisexual men and women have higher rates of a variety of factors that can lead to poor health — things like poverty or involvement with lifestyle activities that can lead to poor health, ” lead author Bridget Gorman tells The Advocate.“A big thing was emotional support. When you compare relative to other groups, bisexuals reported lower rates of getting the emotional support that they felt they needed.”
Bisexual respondents also reported a higher propensity for smoking and using alcohol than straight or gay counterparts — health risks that can be amplified by the higher rates of poverty among the bisexual community compared with other peers. Among gay, lesbian, and straight counterparts, researchers found members of the bisexual community were the least likely to be educated at a university level.
Continue reading on the Advocate.com.
A Yale University study of 38 European countries’ attitudes about homosexuality has uncovered homophobia was associated with gay and bisexual men not seeking HIV-prevention services, HIV testing, and disclosing their orientation to doctors. The authors believed their study highlighted a dangerous trend: One where men who live in more homophobic countries were not only becoming less knowledgeable about HIV treatment, prevention, and resources, but also that this demographic seemingly had more opportunities for sexual activity through “hook-up” mobile applications and websites, a Yale University statement pointed out.
For their study published in the June 19 issue of AIDS, investigators used data from the European MSM Internet Survey (EMIS), a questionnaire that delved into gay and bisexual participants’ HIV-related knowledge, behaviors, and healthcare use.
Continue reading on hcplive.com.
Click on the map to go to AIDSVu interactive online maps
AIDSVu releases its annual interactive online maps that show HIV prevalence data for 34 highly-impacted U.S. cities, including for the first time Birmingham, AL, updated state- and county-level prevalence data, and year-by-year new diagnosis data for 2008 to 2013. HIV testing and treatment locator maps include, for the first time, housing opportunities for persons with AIDS, and also show NIH-funded HIV prevention, vaccine and treatment trials locations.
An ad for FreeHIVTest.net that appeared earlier this spring has caused controversy in Los Angeles, San Francisco, and other areas where it has appeared on billboards and on public transportation kiosks. In the “white” version, the AIDS Healthcare Foundation’s ad features a gay couple in bed, covered only by a sheet and looking ashamed of what they’ve just done. A blond man clutches his pillow and looks suspiciously over the shoulder of the other man who appears to be almost catatonic. Above them, written in big letters is, “Trust Him?”
After the campaign launched this spring in Los Angeles, it’s been slated to appear in Oakland, California; Washington, D.C.; Columbus, Ohio; and Broward County, Florida. In a press release, AHF president Michael Weinstein explained:
“In today’s tabloid culture when it can seem that the game called ‘Life’ should be more appropriately tiled ‘Lies,’ the old adage holds true now more than ever, ‘It’s better to be safe than sorry.’ While infidelity is nothing new, the level of risk in contracting STDS from bed-hopping partners is at an all-time high. We want to remind couples that STDs linger around much longer than a wandering eye and that secret sexual experiences can often produce much more than what one bargained for.”
For some, it’s just a cautionary PSA about the realities of HIV and the importance of getting tested. For others, it’s been seen as a scare tactic to shame people out of having sex and demonize people with HIV — and many have spoofed the ads.
Press release from the HRC…
The Human Rights Campaign (HRC) Foundation, in collaboration with Whitman-Walker Heath (WWH), released an updated guide to practicing safer sex that includes essential tips to minimize the spread of HIV and other sexually transmitted infections (STIs).
The guide, “Safer Sex,” an updated version of the first edition released five years ago, is written for people of all sexual orientations and gender identities, covering topics ranging from basic facts about HIV and STIs, and the importance of practicing safer sex, to the role of new HIV prevention regimens including Pre-Exposure Prophylaxis, or “PrEP.”
The pocket-sized publication is the latest collaboration between the HRC Foundation and WWH, building on their shared commitment to securing the health and well-being of LGBT people in the nation’s capital and beyond.
“It’s a fact that many LGBT people don’t see themselves, or their relationships, discussed in mainstream sexual health resources,” said Jay Brown, the HRC Foundation’s Director of Research and Public Education. “With rates of HIV and other sexually transmitted infections on the rise among young people and in communities of color, HRC and Whitman-Walker remain committed to providing crucial health and wellness information in a way that is medically accurate, culturally competent, and judgement-free.”
Read more on the HRC Website.